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产品信息
CSI 007-01-02
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Human,
Marsupial,
Rat
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1E7-D7/Col3
抗原
Acid-digested pepsin soluble human type III collagen.
偶联物
形式
Liquid
浓度
1.04 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1073771
产品详细信息
CSI 007-01-02 is highly specific for type III collagen. It has been shown to have no cross-reactivity with type I and V collagens by ELISA and immunoblotting. There is no evidence for cross-reactivity with other connective tissue proteins (laminin, fibronectin, elastin). CSI 007-01-02 shows reactivity with human, dog, rat and kangaroo in type III collagens by ELISA and immunoblotting. The antibody does not show reactivity with calf and sheep type III collagen by ELISA and immunoblotting.
CSI 007-01-02 has been successfully used in Western blotting, ELISA, and immunohistochemistry (frozen) procedures. CSI 007-01 has been used successfully for immunohistology on frozen unfixed sections of human and kangaroo skin, and of new dog tissue associated with biomaterial implants. If fixation of tissue is required, acetone or ethanol is recommended.
The specificity of the CSI 007-01-02 epitope is located approximately 100 nm from the N-terminal of the molecule.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
靶标信息
Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I Collagen. Mutations in th gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alpha1 (III) collagen; COL 3; COL3; COL3 alpha 1; Collagen 3; collagen alpha 1 type III; Collagen alpha-1(III) chain; collagen, fetal; collagen, type III, alpha 1; collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant); Collagen3; Ehlers-Danlos syndrome type IV, autosomal dominant; FLJ34534; MGC93704; procollagen, type III, alpha 1
基因别名: COL3A1; EDS4A
UniProt ID: (Human) P02461, (Rat) P13941
Entrez Gene ID: (Dog) 478835, (Human) 1281, (Rat) 84032
skeletal system development
cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
heart development
aging
response to radiation
response to mechanical stimulus
peptide cross-linking
cerebral cortex development
platelet activation
extracellular matrix organization
collagen fibril organization
collagen catabolic process
response to cytokine
positive regulation of Rho protein signal transduction
wound healing
extracellular fibril organization
skin development
digestive tract development
regulation of immune response
negative regulation of immune response
aorta smooth muscle tissue morphogenesis
cellular response to amino acid stimulus
negative regulation of neuron migration
blood vessel development
